Best Gut Health Supplements 2025

Try To Avoid

Uncertain CFU count - CFUs, or colony-forming units, are a method of counting how much live bacteria is in a probiotic product. The amount of CFUs can vary from product to product and can change from 1 to 10 billion (though more is not always better).*
Lack of Third-Party Testing - Always look for ‘third party lab-tested’ verifications that guarantee the product has been independently tested for any heavy metals, bacteria, pesticides, or traces of any other harmful substances. This helps to ensure safety and efficacy of the product.*
Extremely Low or High Price - Do your research before buying an overpriced or suspiciously cheap supplement. Do not cut corners for your gut health.

Common Ingredients In Gut Support Supplements

Probiotics – Probiotics are “good” bacteria and yeasts, thought to benefit the digestive system by helping to maintain gut balance. There are many different strains of probiotics.*
Prebiotics – Prebiotics are a form of dietary fiber that acts as a source of food for the “good” bacteria in your gut.*
Synbiotics – Synbiotics are a combination of probiotics and prebiotics, their name comes from the fact that they create synergy between probiotics and the specific fiber they need to feed on.*
Postbiotics – Postbiotics are the “waste” product of probiotics feeding on prebiotics. They are bioactive compounds like short-chain fatty acids, that are associated with a number of health benefits.*
Digestive enzymes – Digestive enzymes play a key role in breaking down the food you eat.*

Top 5 Gut Supplements Of 2025

Primal Gut Restore by Primal Harvest[1]

Bio Complete 3 by GundryMD

Zupoo by UMZU

Flatter Me by HUM Nutrition

Synbiotics by BeLive

Key Ingredients To Look For

Important Criteria

*We try to update product information as often as we can. Please visit product websites for more information.

Prebiotics

Probiotics

Postbiotics

Ingredients To Avoid

*These statements have not been evaluated by the FDA Food & Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.

Note: The information contained within this site is not intended as a substitute for professional medical advice. If you have, expect to have, or suspect you may have any medical condition, you are urged to consult with a healthcare provider. All content, including text, graphics, images, and information, contained on or available through this website is for general information purposes only. Results do not necessarily reflect typical results from the use of these products. Please visit product websites for more information.

Trademarks utilized on our website belong to their respective owners and no implied or expressed endorsement of our website or services is intended. Rankings can be affected by the relationship Top5 Wellness has with our picks.

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Bottom Line:

Gut Restore by Primal Harvest is an all-in-one gut support formula that contains pre-, pro- and postbiotics. It is formulated with the trademarked CoreBiome™️ tributyrin postbiotic, 3 billion CFUs of B. Longum BB536® probiotics, and xyliooligosaccharide prebiotics. The capsules are easy to swallow and liked the two-capsule serving size as it made it easy to add to our supplement routine. All in all, you may feel that this product offered everything you are looking for in a gut supplement, making it your favorite from the products you have tried.

Additionally, the formula is third-party lab-tested and made in the USA with globally sourced ingredients. To top it off, they’re backed by a 90-day money-back guarantee. You may notice that the product was fairly priced, especially when you buy multiple bottles or sign up for the brand’s easy and convenient subscription service.

PROS

CONS

1. Primal Gut Restore

by Primal Harvest[1]

Rating A+

Our rating:

Formulated with CoreBiome™️ Tributyrin postbiotics
Contains 3 bill. CFUs of B. Longum BB536® probiotics
Made with pre, pro, and postbiotics
Third-party lab-tested
USA-made with globally sourced ingredients
90-day Money-Back-Guarantee

Only available online
Sometimes runs out of stock

How we rated the Top 5 Nutritional Supplements

Each of our reviews is based on a factual analysis and comparison. We examine the ingredients, dosages and manufacturing processes to understand the quality of the product. In addition, we evaluate customer reviews, value for money and customer service to protect our readers from negative buying experiences. Although we may receive compensation for these reviews, we strive to provide objective comparisons based on facts.

EFFECTIVENESS

INGREDIENTS

PRICE-PERFORMANCE

CUSTOMER SERVICE

Top Supplements 2025

No Refrigeration Required

90-Day Money-Back Guarantee

Subscription Service

Third-Party Lab-Tested

Bottom Line:

Bio Complete 3 by GundryMD contains a blend of pre, pro, and postbiotics. While this product has a comprehensive formula, the serving size is 2 capsules to take each day. You may also want to note that at $69.95, this option is a little pricier than some of the others on this list.

PROS

CONS

2. Bio Complete 3

by GundryMD

Rating: B+

Our rating:

Contains pre & probiotics
90-day money-back guarantee
Doctor-formulated

Glass bottle
Does not note if it is a gelatin or vegetable capsule

Bottom Line:

Zupoo by UMZU is formulated with extracts including Cascara Sagrada, bentonite clay, aloe ferox, milk thistle, and cayenne pepper extract. The product contains sustainably sourced ingredients and is produced in a CGMP-certified facility, it does not contain any probiotics, prebiotics, or postbiotics. Additionally, it is fairly expensive when considering that one bottle only contains a 15-day supply.

PROS

CONS

3. Zupoo

by UMZU

Rating B

Our rating:

Chemist-formulated
Variety of ingredients
Two capsule serving size
Produced in a CGMP facility

No pre-, pro-, or postbiotics
Price (only a 15-day supply)

Bottom Line:

Flatter Me by HUM Nutrition combines extracts from ginger, fennell, and peppermint with 18 digestive enzymes. It should be taken before meal times. Although it contains digestive enzymes and a range of extracts, it does not contain pro- and postbiotics. The fact that it needs to be taken before meals may be inconvenient for some users as they would need to carry the product around with them.

PROS

CONS

4. Flatter Me

by HUM Nutrition

Rating C+

Our rating:

With ginger, fennel seed, and peppermint
Formulated with digestive enzymes
Vegan-friendly capsules and formula
Clean Label Project certified

No probiotics
Must be taken before meals

Our Choice 2025

Based on 3739 Reviews of Primal Harvest

Primal Gut Restore

by Primal Harvest[1]

USA-made with globally sourced ingredients
Third-Party Lab-Tested
3-in-1 Gut Formula
90-Day Money-Back Guarantee
Pre-, Pro-, and Postbiotics

Bottom Line:

Synbiotics by BeLive is a prebiotic and probiotic formula that comes in flavored gummy form. Although these gummies include bacillus coagulans and prebiotic fiber, they are formulated without postbiotics and are therefore a 2-in-1 formula. Those watching their sugar intake may also want to note that these gummies contain tapioca syrup and sugar.

PROS

CONS

5. Synbiotics

by BeLive

Rating C

Our rating:

Contains pre- and probiotics
No corn syrup present
Gummies are easy to chew and swallow

Contains tapioca syrup and stevia as sweeteners
Some users reported little improvements from the product

Citations

DISCLAIMER: This scientific research is for informational purposes only. The results reported may not necessarily occur in all individuals. Wellness Reviews provides this information as a service but does not endorse it. This information should not be read to recommend or endorse any specific products.

1. Integrative HMP (iHMP) Research Network Consortium. “The Integrative Human Microbiome Project: dynamic analysis of microbiome-host omics profiles during periods of human health….” Cell host & microbe vol. 16,3 (2014): 276-89. doi:10.1016/j.chom.2014.08.014

2. Sender, Ron et al. “Revised Estimates for the Number of Human and Bacteria Cells in the Body.” PLoS biology vol. 14,8 e1002533. 19 Aug. 2016, doi:10.1371/journal.pbio.1002533

3. Durack, Juliana, and Susan V Lynch. “The gut microbiome… opportunities for therapy.” The Journal of experimental medicine vol. 216,1 (2019): 20-40. doi:10.1084/jem.20180448

4. Al Bander, Zahraa et al. “The Gut Microbiota…An Overview.” International journal of environmental research and public health vol. 17,20 7618. 19 Oct. 2020, doi:10.3390/ijerph17207618

To see a list of our other references, please click here.

It All Starts In Your Gut

Bloating, constipation, indigestion

Acne or other skin issues

Immune health

Bloating, constipation, indigestion? Acne or other skin issues? It may be stemming from your gut. Feeling run down and sluggish? It could also be related to your gut.[1, 2, 3]

Researchers have become increasingly interested in exploring the gut and its role in so many major areas of our health. But it seems like we’re only just beginning to scratch the surface when it comes to truly understanding the immensely complex connection between gut microbiome health and its impact on our overall well-being.[1, 2, 3]

The gut microbiome plays so many essential roles in the human body, it’s sometimes referred to as “a supporting organ”. It can affect many aspects of health, ranging from the gut to the immune system to brain health.[3]

Everyone’s gut microbiome is entirely unique and can be impacted by things like diet and our surrounding environment.[5]

It’s likely that our modern lifestyles may have been wreaking havoc on our gut microbiota for years. Eating more processed and sugary foods, experiencing more stress, sleeping less, and being more sedentary, can all contribute to imbalance in the gut microbiome.[1, 2, 3, 4]

Whenever you see the term “gut microbiome,” it’s referring to all of the microorganisms living within your gut. Some of them may be potentially harmful, so-called “bad” bacteria. On the other hand, some are thought to be beneficial, often called “good” or “friendly” bacteria.[1, 2, 3, 4]

Researchers believe that having optimal gut health typically means having a good balance between the “bad” bacteria and the “good’ bacteria. Ideally, they should co-exist peacefully within the gut.[1, 2, 3, 4]

What Exactly Is Your Gut Microbiome?

Probiotics + Prebiotics = Postbiotics

Haven’t heard of postbiotics? You’re most definitely not alone. A fairly new term in the health and wellness world, researchers have recently begun exploring the potential of postbiotics when it comes to supporting the gut. Postbiotics are what’s created when “good” gut bacteria feeds on prebiotic fibers. In other words, prebiotics + probiotics = postbiotics.

Postbiotics are what’s left at the end, once the “good” bacteria has fed on fiber (prebiotics). They include a number of substances and nutrients such as amino acids, vitamins, as well as short-chain fatty acids.

Short-chain fatty acids are a particularly interesting type of postbiotic because they are thought to contribute to supporting gut health. This is because studies suggest that they can help the “friendly” bacteria flourish in the gut. One of the most prevalent of these is called butyrate, which is believed to support both gut and intestinal health.*

There are plenty of gut health supplements on the market today that promise to restore the balance of your gut. Yet it can be difficult to navigate an overwhelming variety of supplements and their ingredients.

Knowing what to look for and what to try to avoid can help you make an informed decision when shopping for a gut supplement.

Brain fog and mood

Why Is The Gut Microbiome Important?

How To Support Your Gut Health

Helping us digest our food better*

Supporting overall gut health*

Promoting a balanced gut bacteria, aka microbiome*

Changing your diet, sleeping more, avoiding stressful situations, exercising and avoiding sugar might sound simple but aren't always as easy to follow through with.

That's why some people may turn to supplements such as probiotics and prebiotics to support their gut health.*

Some potential benefits of probiotics and prebiotics include:

Support healthy regularity*

Support digestive concerns*